Tenofovir Alafenamide Hemifumarate|DC Chemicals

Tenofovir Alafenamide Hemifumarate|DC Chemicals

GS-7340(Tenofovir alafenamide) is a prodrug of tenofovir (TFV) that more efficiently delivers TFV into lymphoid cells and tissues than TFV disoproxil fumarate.

Product Name: Tenofovir Alafenamide Hemifumarate|Cat No. DC9294|cas: 1392275-56-7|Other names: Tenofovir alafenamide; GS7340; GS 7340| Molecule formular: C46H62N12O14P2Molecule Weight: 1068.4

GS-7340(Tenofovir alafenamide) is a prodrug of tenofovir (TFV) that more efficiently delivers TFV into lymphoid cells and tissues than TFV disoproxil fumarate.
IC50 value:
Target: NRTI; HIV reverse transcriptase inhibitor
GS-7340 reduces first-pass clearance to be an effective oral prodrug, its permeability and stability were characterized in vitro and detailed pharmacokinetic studies were completed in dogs. GS-7340 showed concentration-dependent permeability through monolayers of caco-2 cells and dose-dependent oral bioavailability in dogs, increasing from 1.7% at 2 mg/kg to 24.7% at 20 mg/kg, suggesting saturable intestinal efflux transport [1]. Significant reductions in plasma HIV-1 RNA from baseline to day 11 were observed for all TAF dose groups compared with placebo (P < 0.01), with a median decrease of 1.08-1.73 log10 copies per milliliter, including a dose-response relationship for viral load decrease up to 25 mg [2].. For the detailed information of GS-7340, the solubility of GS-7340 in water, the solubility of GS-7340 in DMSO, the solubility of GS-7340 in PBS buffer, the animal experiment (test) of  GS-7340, the cell expriment (test) of GS-7340, the in vivo, in vitro and clinical trial test of GS-7340, the EC50, IC50,and affinity,of GS-7340, Please contact DC Chemicals.

For research and scientific purpose only, not for human use!