BMS687453|CAS 1000998-59-3|DC Chemicals

BMS687453|CAS 1000998-59-3|DC Chemicals

BMS687453 is a potent and selective peroxisome proliferator activated receptor (PPAR) α agonist, with an EC50 of 10 nM for human PPARα and ∼410-fold selectivity vs human PPARγ in PPAR-GAL4 transactivation assays.

Product Name: BMS-687453|Cat No. DC9252|cas: 1000998-59-3|Other names: BMS-687453，BMS687453，BMS 687453| Molecule formular: C22H21ClN2O6Molecule Weight: 444.865

BMS687453 is a potent and selective peroxisome proliferator activated receptor (PPAR) α agonist, with an EC50 of 10 nM for human PPARα and ∼410-fold selectivity vs human PPARγ in PPAR-GAL4 transactivation assays. Similar potencies and selectivity were also observed in the full length receptor co-transfection assays. BMS687453 has negligible cross-reactivity against a panel of human nuclear hormone receptors including PPARδ. BMS687453 demonstrated an excellent pharmacological and safety profile in preclinical studies and thus was chosen as a development candidate for the treatment of atherosclerosis and dyslipidemia.