Elbasvir(MK-8742)|CAS 1370468-36-2|DC Chemicals

Elbasvir(MK-8742)|CAS 1370468-36-2|DC Chemicals

Elbasvir (MK-8742) is a small-molecule inhibitor of nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) being developed as a component of treatment regimens for chronic HCV infection.

Product Name: Elbasvir(MK-8742)|Cat No. DC9295|cas: 1370468-36-2|Other names: MK-8742; MK8742; MK 8742| Molecule formular: C49H55N9O7Molecule Weight: 882.02

Elbasvir possesses activity against genotype 1a, 1b, and 3 in vitro, including against some viral variants resistant to other NS5A inhibitors. In a phase 1b dose escalation study, Elbasvir once daily for 5 days resulted in mean reductions in HCV RNA levels of 3.7 to 5.1 log10IU/ml in patients with genotype 1a or 1b infections given 5 to 50 mg/day and of  3 log10 IU/ml in patients with genotype 3 given 50 or 100 mg/day. In later phase 2 trials, treatment with Elbasvir combined with Grazoprevir (MK-5172, an investigational once-daily NS3/4A protease inhibitor) with or without Ribavirin for 12 weeks produced rates of sustained virological response at week 12 (SVR12) of 87 to 98% for patients with genotype 1 infections, including in historically difficult-to-treat subgroups.

For research and scientific purpose only, not for human use!