Pravadoline(WIN 48,098)|CAS 92623-83-1|DC Chemicals

Pravadoline(WIN 48,098)|CAS 92623-83-1|DC Chemicals

Pravadoline is a cannabimimetic aminoalkylindole agonist of the cannabinoid receptors and an inhibitor of Cox-1 and Cox-2, demonstrating powerful analgesic effects through the combination of these actions.

Product Name: Pravadoline(WIN 48,098)|Cat No. DC8887|cas: 92623-83-1|Other names: | Molecule formular: C23H26N2O3Molecule Weight: 378.5

Pravadoline is a nonacidic, aminoalkylindole analgesic agent that inhibits cyclooxygenase.1 Like NSAIDs, pravadoline inhibits prostaglandin synthesis (IC50 = 5 μM in mouse brain microsomes) and displays antinociceptive activity (ED50 = 26 mg/kg in an acetylcholine-induced writhing assay in mice).In contrast to NSAIDs, pravadoline inhibits neuronally stimulated contractions in mouse vas deferens preparations (IC50 = 0.45 μM), an effect similar to that which is produced by opioid analgesics, yet is not attenuated by the opioid receptor antagonist, naloxone.1 Pravadoline does not produce gastrointestinal irritation following acute or chronic administration to rodents.

For research only, not for human use!