Paracetamol|cas 103-90-2|DC Chemicals

Paracetamol|cas 103-90-2|DC Chemicals

Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor.

Product Name: Paracetamol|Cat No. DC8949|cas: 103-90-2|Other names: | Molecule formular: C8H9NO2Molecule Weight: 151.16

Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor.Acetaminophen acts functionally as a selective COX-2 inhibitor led us to investigate the hypothesis of whether it works via preferential COX-2 blockade. In vitro, acetaminophen elicited a 4.4-fold selectivity toward COX-2 inhibition (IC(50)=113.7 micromol/L for COX-1; IC(50)=25.8 micromol/L for COX-2). Following oral administration of the drug, maximal ex vivo inhibitions were 56% (COX-1) and 83% (COX-2). Acetaminophen plasma concentrations remained above the in vitro IC(50) for COX-2 for at least 5 h postadministration. Ex vivo IC(50) values (COX-1: 105.2 micromol/L; COX-2: 26.3 micromol/L) of acetaminophen compared favorably with its in vitro IC(50) values. In contrast to previous concepts, acetaminophen inhibited COX-2 by more than 80%, i.e., to a degree comparable to nonsteroidal antiinflammatory drugs (NSAIDs) and selective COX-2 inhibitors. However, a >95% COX-1 blockade relevant for suppression of platelet function was not achieved.

For research only, not for human use!