DEL-22379|cas 181223-80-3| DC Chemicals

DEL-22379|cas 181223-80-3| DC Chemicals

DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ∼0.5 μM.

Product Name: DEL-22379|Cat No. DC8866|cas: 181223-80-3|Other names: DEL22379,DEL 22379,DEL-22379| Molecule formular: C26H28N4O3Molecule Weight: 444.53

DEL-22379 is an ERK dimerization inhibitor with IC50 of  0.5 μM.
in vitro: DEL-22379 inhibits ERK dimerization without affecting its
phosphorylation. DEL-22379 blocks proliferation of tumor cells harboring RASERK pathway oncogenes. Pretreating cells with DEL-22379 inhibits EGF-stimulated RSK1 phosphorylation, with estimated IC50 values of 500 nM for DEL-22379.
in vivo: In animal tumor models, DEL-22379 induces apoptosis,
preventing tumor progression.DEL-22379 abolishes EGF-induced co-immunoprecipitation of ectopic ERK2 molecules tagged with hemagglutinin (HA) or FLAG epitopes, with an estimated half-maximal inhibitory concentration (IC50) of 0.5 uM.

For research only, not for human use!