NCT-503|NCT-503|PHGDH INHIBITOR

NCT-503|NCT-503|PHGDH INHIBITOR

DC Chemicals, Website: www.dcchemicals.com

Product Name: NCT-503|Cas Number: 1916571-90-8| Catalog Number: DC10486|Other Nmaes: NCT 503,NCT503

NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells with an IC50 value of 2.5 µM.

NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells with an IC50 value of 2.5 µM. It has been shown to reduce the production of glucose-derived serine in cells and to suppress the growth of PHGDH-dependent MDA-MB-468 cancer cells both in vitro and in mice bearing orthotopic xenograft tumors.