Wnt Inhibitor IWP-4|Differentiation Inducer

Wnt Inhibitor IWP-4|Differentiation Inducer

Wnt Inhibitor IWP-4 is a potent inhibitor of Wnt/β-catenin signaling (IC50 = 25 nM).

Product Name: IWP-4|Cat No. DC9812|CAS: 686772-17-8|Other names:IWP4,IWP 4|MW: 496.6|Molecule Formular: C23H20N4O3S3|Purity>98%

Wnt Inhibitor IWP-4 was identified in a high throughput screen for antagonists of the Wnt / β-catenin pathway. Wnt Inhibitor IWP-4 prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, there by blocking Wnt secretion and activity. It also blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin. IWP-4 has been shown to block Wnt-dependent phosphorylation of the low-density lipoprotein receptor-related protein 6 receptor and the scaffold protein Dishevelled, preventing the accumulation of β-catenin. IWP-4 has been used to induce cardiomyocyte differentiation from human pluripotent stem cells.