IC-261(SU-5607)|CK1 inhibitor

IC-261(SU-5607)|CK1 inhibitor

IC261 is a novel inhibitor of CK1, triggers the mitotic checkpoint control. The IC50 of IC261 for CK1 was 16 μM and for Cdk5 is 4.5 mM.

Product Name: IC-261(SU-5607)|Cat No. DC9730|CAS: 186611-52-9|Other names:IC261,SU5607,IC 261,SU 5607|MW: 311.33|Molecule Formular: C18H17NO4|Purity>98%

 IC261 is a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects. At low micromolar concentrations IC261 inhibits cytokinesis causing a transient mitotic arrest. IC261 selectively inhibits CK1 compared to other protein kinases by an ATP-competitive mechanism.

For research only, not for human use.