HA15|HA-15|CAS 1609402-14-3

HA15|HA-15|CAS 1609402-14-3

HA15 displayed anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors.

Product Name: HA-15|Cat No. DC9795|CAS: 1609402-14-3 |Other names:HA15，HA 15|MW: 466.11|Molecule Formular: C23H22N4O3S2|Purity>98%

HA15 displayed anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors. HA15 also exhibited strong efficacy in xenograft mouse models with melanoma cells either sensitive or resistant to BRAF inhibitors. Transcriptomic, proteomic, and biochemical studies identified the chaperone BiP/GRP78/HSPA5 as the specific target of HA15 and demonstrated that the interaction increases ER stress, leading to melanoma cell death by concomitant induction of autophagic and apoptotic mechanisms.