LY3177833|LY-3177833|CDC7 inhibitor

LY3177833|LY-3177833|CDC7 inhibitor

LY3177833 is a novel CDC7 inhibitor,CDC7/DBF4 IC50 = 3.3 nM, pMCM2 (S53) IC50 = 290 nM and IVTI TEC70 = 1.6 mcM.

Product Name: LY3177833|Cat No. DC9766|CAS: 1627696-51-8|Other names:LY 3177833,LY-3177833|MW: 309.3|Molecule Formular: C16H12FN5O|Purity>98%

LY3177833 is a novel CDC7 inhibitor,CDC7/DBF4 IC50 = 3.3 nM, pMCM2 (S53) IC50 = 290 nM and IVTI TEC70 = 1.6 mcM. LY-3177833 showed MED = 5 mg/kg (p.o.) in vivo. LY-3177833 strongly impacted chromosome dynamics. In mouse xenograft models, broad antitumor activity was associated with robust dose/exposure-dependent in vivo target inhibition. In addition, the preclinical profile of LY-3177833 was different from nonselective CDC7 inhibitors and cytotoxic agents, something that supports its clinical development with a continuos dosing regime