A-1155463|A1155463| BCL-XL inhibitor

A-1155463|A1155463| BCL-XL inhibitor

A-1155463 is a highly potent and selective BCL-XL inhibitor.

Product Name: A1155463|Cat No. DC9768|CAS: 1235034-55-5|Other names:A-1155463; A 1155463; A1155463.|MW: 669.79|Molecule Formular: C35H32FN5O4S2 |Purity>98%

A-1155463 is a highly potent and selective BCL-XL inhibitor. A-1155463 is substantially more potent against BCL-XL-dependent cell lines relative to WEHI-539, while possessing none of its inherent pharmaceutical liabilities. A-1155463 caused a mechanism-based and reversible thrombocytopenia in mice and inhibited H146 small cell lung cancer xenograft tumor growth in vivo following multiple doses. A-1155463 thus represents an excellent tool molecule for studying BCL-XL biology as well as a productive lead structure for further optimization.