STF-62247|STF62247|TGN inhibitor

STF-62247|STF62247|TGN inhibitor

DC Chemicals, Website: www.dcchemicals.com

Product Name: STF-62247|Cas Number: 315702-99-9| Catalog Number: DC10456|Other Nmaes: STF-62247,STF 62247,STF62247

STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM).

STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM). It significantly reduces the growth rate of tumors formed from VHL-deficient cells in mice.1,2,3 STF-62247 induces cytotoxicity in VHL-positive RCC cells only at higher concentrations (IC50 = 16 μM).