NE100|NE-100|sigma-1 (σ1) receptors antagonist

NE100|NE-100|sigma-1 (σ1) receptors antagonist

DC Chemicals, Website: www.dcchemicals.com

Product Name: NE-100|Cas Number: 149409-57-4| Catalog Number: DC10455|Other Nmaes: NE100,NE 100

NE100 hydrochloride is a potent and selective σ1 receptor antagonist (Ki = 0.86 nM) that displays > 55-fold selectivity over σ2 receptors and > 6000-fold selectivity over D1

Potent and selective σ1 receptor antagonist (Ki = 0.86 nM) that displays > 55-fold selectivity over σ2 receptors and > 6000-fold selectivity over D1, D2, 5-HT1A, 5-HT2 and PCP receptors. Exhibits reversible binding (Kd = 1.2 nM) and displays antipsychotic activity in vivo. Orally active.