PT2385|PT2385|HIF-2 alpha inhibitor

PT2385|PT2385|HIF-2 alpha inhibitor

DC Chemicals, Website: www.dcchemicals.com

Product Name: PT2385|Cas Number: 1672665-49-4| Catalog Number: DC10464|Other Nmaes: PT 2385,PT-2385

PT2385 is an orally active, small molecule inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic activity.

PT2385 is an orally active, small molecule inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic activity. Upon oral administration, HIF-2alpha inhibitor PT2385 allosterically binds to HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its subsequent binding to DNA. This results in decreased transcription and expression of HIF-2alpha downstream target genes, many of which regulate tumor cell growth and survival.