ADX-88178|ADX-88178|mGlu4 receptor odulator

ADX-88178|ADX-88178|mGlu4 receptor odulator

DC Chemicals, Website: www.dcchemicals.com

Product Name: ADX-88178|Cas Number: 1235318-89-4| Catalog Number: DC10465|Other Nmaes: ADX-88178,ADX 88178,ADX88178

ADX-88178 is a novel potent, selective, and brain-penetrant positive allosteric modulator of the mGlu4 receptor.

ADX-88178 is a novel potent, selective, and brain-penetrant positive allosteric modulator of the mGlu4 receptor in rodent models of anxiety, obsessive compulsive disorder (OCD), fear, depression, and psychosis. ADX88178 dose-dependently reduced the number of buried marbles in the marble burying test and increased open-arm exploration in the elevated plus maze (EPM) test, indicative of anxiolytic-like efficacy.