Tie-2 inhibitor 7|cas 1020412-97-8|DC Chemicals

Tie-2 inhibitor 7|cas 1020412-97-8|DC Chemicals
An agent that inhibits endothelial cell tube formation

Catlog: DC8045| Product name: Tie-2 inhibitor 7| Cas: 1020412-97-8| Other names: Tie2 inhibitor,Tie inhibitor 7| Molecule Formula: C31H29N3O5| MW: 523.6. Purity: >98%

Price: 10mg: 400 USD; 250mg: 800 USD; 1000mg: 1600 USD

Tie-2 Inhibitor 7 can permeate the cell (IC50= 1μM) and inhibit endothelial cell tube formation. Research shows that it can block the Tie-2 ligand, Ang-1 (angiopoietin), which induces Tie-2 autophosphorylation and block its downstream signaling with an IC50= 0.3 μM. Vascular leakage, suppression of endothelial apoptosis, and vessel regression are strongly inhibited by Ang-1. The Tie-2 receptor plays a crucial role in the normal and pathologic vascular development of epithelial cells.

For research and scientific purpose only, not for human use.