Purvalanol A(NG 60)|CDK inhibitor|DC Chemicals

Purvalanol A(NG 60)|CDK inhibitor|DC Chemicals
Purvalanol A is a potent, cell-permeable cyclin-dependent protein kinase (cdk) inhibitor.

Catlog: DC8075| Product name: Purvalanol A(NG 60)| Cas: 212844-53-6| Other names: NG 60,NG60,NG-60| Molecule Formula: C19H25ClN6O| MW: 388.89. Purity: >98%

Price: 100mg: 550 USD; 250mg: 950 USD; 1000mg: 1800 USD

Purvalanol A is a potent, cell-permeable, and selective inhibitor of cyclin-dependent kinases (CDKs) with IC50 values of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively. Purvalanol A reversibly arrests synchronized cells in the G1 and G2 phase of the cell cycle, inhibiting both cell proliferation and cell death.At 10 μM, purvalanol A potently suppresses the anchorage-independent growth of c-Src-transformed cells as well as HT29 and SW48 human colon cancer cells.

For research and scientific purpose only, not for human use.