AZ5104(AZ-5104),metabolite of AZD9291|DC Chemicals

AZ5104(AZ-5104),metabolite of AZD9291|DC Chemicals
AG-120 is a first-in-class, orally available, selective, potent inhibitor of the mutated IDH1 protein.

Catlog: DC8052| Product name: AZ5104| Cas: 1421373-98-9| Other names: AZ-5104,AZ 5104| Molecule Formula: C27H31N7O2| MW: 485.58. Purity: >98%

Price: 100mg: 750 USD; 250mg: 1500 USD; 1000mg: 2600 USD

AZ5104 is an active circulating metabolite of AZD9291. It shares the similar overall activity profile with AZD9219, but is more potent against mutant EGFR forms, while hitting the wild-type EGFR form at a lower concentration thus demonstrating a smaller selectivity margin compared with the parent. Like AZD9291, AZ5104 displays potent antitumor activities both in vitro and in vivo, and is clinically competent with the parent.AZ5104 is a demethylated metabolite of AZD-9291. AZ-5104 was identified to exhibit 5-fold potency compared to AZD-9291, which is currently in clinical trial.

For research and scientific purpose only, not for human use.