GSK-503|GSK503|EZH2 inhibitor|DC CHEMICALS

GSK-503|GSK503|EZH2 inhibitor|DC CHEMICALS
GSK503 is a specific EZH2 methyltransferase inhibitor.

Catlog: DC8044| Product name: GSK-503| Cas: 1346572-63-1| Other names: GSK-503,GSK503,GSK 503| Molecule Formula: C31H38N6O2| MW: 526.3. Purity: >98%

Price: 100mg: 950 USD; 250mg: 1800 USD; 1000mg: 3000 USD

GSK503 is a specific EZH2 methyltransferase inhibitor or vehicle. GSK503 was designed by performing high-throughput screening for EZH2 methyltransferase inhibiting compounds followed by chemical optimization.GSK503 inhibits the methyltransferase activity of WT and mutant EZH2 with similar potency (Kappi=3−27nM) and is structurally related to GSK126 and GSK343. GSK503 was > 200 fold selective over EZH1 (Kappi=636nM) and > 4000 fold selective over other histone methyltransferases. GSK503 displayed favorable pharmacokinetics in mice and was thus selected for use in in vivo experiments.

For research and scientific purpose only, not for human use.