EVP-6124 supplier|EVP6124|DC Chemicals

EVP-6124 supplier|EVP6124|DC Chemicals
DC Chemicals provides EVP-6124, other names: EVP6124,EVP 6124, cas: 550999-74-1. In stock.

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EVP-6124 is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).

EVP-6124, other names: EVP6124,EVP 6124, cas: 550999-74-1, Molecule formular: C16H18Cl2N2OS, Molecule Weight: 357.3, Chemical name: N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-7-chloro-1-benzothiophene-2-carboxamide;hydrochloride

EVP-6124 Hcl is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs). EVP-6124 showed selectivity for α7 nAChRs and did not activate or inhibit heteromeric α4β2 nAChRs.EVP-6124, its alpha-7 nicotinic acetylcholine receptor agonist, possesses a novel mechanism not previously seen in the scientific community: it acts as a co-agonist with Acetylcholine (ACh) to enhance cognition. By acting as a co-agonist and sensitizing the alpha-7 receptor, EVP-6124 makes it possible for smaller amounts of naturally occurring ACh, typically found in individuals with memory disorders such as Alzheimer's, to be required to activate the receptor.  In this scenario, research demonstrated that memory deficits can be minimized or entirely reversed by controlling the neuronal channel with EVP-6124 alone or in combination with other Alzheimer's drugs.
For the detailed information of EVP-6124, the solubility of EVP-6124 in water, the solubility of EVP-6124 in DMSO, the solubility of EVP-6124 in PBS buffer, the animal experiment (test) of  EVP-6124, the cell expriment (test) of EVP-6124, the in vivo, in vitro and clinical trial test of EVP-6124, the EC50, IC50,and affinity,of EVP-6124, Please contact DC Chemicals.