DC Chemicals Supply: VGX-1027, Cas: 6501-72-0 ,Cat No. DC7528, Purity>98%, In stock.
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VGX-1027|cas 6501-72-0, Synonym name: GIT27; GIT 27; GIT-27; VGX1027; VGX 1027, Chemical name: 4,5-Dihydro-3-phenyl-5-isoxazoleacetic acid, Molecule weight: 205.21, Molecule Formula: C11H11NO3
VGX-1027(GIT27) is an isoxazole compound that exhibits various immunomodulatory properties; reduce the secretion of IL-1beta, TNF-alpha and IL-10 from purified murine macrophages.
VGX-1027 significantly inhibits both IL-1β/IFN-γ-induced TNF-α and nitrite accumulation, and causes a significant increase in cell survival by interfering with the cytotoxic effects of the cytokines. [1] VGX-1027 inhibits both proliferation of enterobacterial antigen-reactive CD4+CD25? T cells in vitro. [2] VGX-1027 prevents development of spontaneous type 1 diabetes in NOD Mice and counteracts accelerated diabetogenesis induced by cyclophosphamide challenge or adoptive transfer of diabetogenic spleen cells in NOD Mice. VGX-1027 also reduces clinical signs of MLD-STZ-induced diabetes and suppresses pathohistological changes of pancreas. [1] VGX-1027 suppresses the development of clinical, histological and immunological signs of DNBS-induced colitis in CD1 mice. [2] In NZB/NZW F1 model of systemic lupus erythematosus (SLE), VGX-1027 ameliorates the course of the disease with higher percent survival and improved clinical and histopathological signs. [3]
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