DC Chemicals Supply: SU1498, Cas: 168835-82-3 ,Cat No. DC7509, Purity>98%, In stock.
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SU1498|cas 168835-82-3, Synonym name: su1498, Tyrphostin SU 1498, CHEMBL261508, (E)-2-CYANO-3-(4-HYDROXY-3,5-DIISOPROPYLPHENYL)-N-(3-PHENYLPROPYL)ACRYLAMIDE, Chemical name: , Molecule weight: 390.517, Molecule Formula: C25H30N2O2
SU1498 has shown the ability to be a reversible, potent ATP-competitive and selective inhibitor of Flk-1kinase, a vascular endothelial growth factor (VEGF) receptor kinase. Additionally, SU1498 has been shown to reduce the expression of ets-1, a transcription factor stimulated by VEGF. Demonstrates a weakly inhibitory effect on PDGF-receptor, EGF-receptor, and HER2 kinases. SU1498 potentially acts as an angiogenesis inhibitor as shown by its activity in the chorioallantoic membrane (CAM) assay.
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