DC Chemicals Supply: RO4987655, Cas: 874101-00-5 ,Cat No. DC7488, Purity>98%, In stock.
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RO4987655|cas 874101-00-5, Synonym name: RO-4987655; RO 4987655; CH-4987655; CH4987655; CH 4987655, Chemical name: , Molecule weight: 565.28, Molecule Formula: C20H19F3IN3O5
RO4987655(CH-4987655) is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1/MEK1 IC50=5.2 nM), with potential antineoplastic activity.
RO4987655(CH-4987655) is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1/MEK1 IC50=5.2 nM), with potential antineoplastic activity.
IC50 value: 5.2 nM
Target: MEK1/2
MEK inhibitor RO4987655 binds to and inhibits MEK, which may result in the inhibition of MEK-dependent cell signaling and the inhibition of tumor cell proliferation. MEK, a dual specificity threonine/tyrosine kinase, is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers.
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