DC Chemicals Supply: TCS 1102, Cas: 916141-36-1 ,Cat No. DC7513, Purity>98%, In stock.
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TCS 1102|cas 916141-36-1, Synonym name: TCS1102; TCS-1102, Chemical name: , Molecule weight: 470.59, Molecule Formula: C27H26N4O2S
TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively).
TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively).
IC50 value: 0.2 nM (Ki, OX2 receptor); 3 nM (Ki, OX1 receptor) [1]
Target: OX2 and OX1 receptor
TCS-1102 (10 and 20 mg/kg, i.p.) were found to decrease fear and anxiety in rats 14 days after exposure to footshock.Furthermore, TCS-1102 (10 mg/kg, i.p.) was found to have anxiolytic effects that were specific for HR when tested in the elevated T-maze. [2]
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