DC Chemicals Supply: TAC-101, Cas: 125973-56-0 ,Cat No. DC7510, Purity>98%, In stock.
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TAC-101|cas 125973-56-0, Synonym name: , Chemical name: 4-[3,5-Bis(trimethylsilyl) benzamido] benzoic acid, Molecule weight: 385.60428 , Molecule Formula: C20H27NO3Si2
amsilarotene (TAC-101) is a retinobenzoic acid with potential antineoplastic activity. TAC-101 inhibits retinoblastoma-gene product (RB) phosphorylation and increases the presence of 2 cyclin-dependent kinase (CDK) inhibitors, resulting in cell cycle arrest. This agent also causes a cytotoxic decline in cyclin A and thymidylate synthase expression. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
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