RPI-1 supplier|RPI1|DC Chemicals

RPI-1 supplier|RPI1|DC Chemicals
DC Chemicals provides RPI-1, other names: RPI1,RPI 1, cas: 269730-03-2. In stock.

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RPI-1 is a cell-permeable ATP-competitive tyrosine kinase inhibitor

RPI-1, other names: RPI1,RPI 1, cas: 269730-03-2, Molecule formular: C17H15NO4, Molecule Weight: 297.31, Chemical name: RET Receptor Tyrosine Kinase Inhibitor; 1,3-dihydro-5,6-dimethoxy-3-[(4-hydroxyphenyl)methylene]-H-indol-2-one; (3E)-3-[(4-hydroxyphenyl)methylidene]-5,6-dimethoxy-1H-indol-2-one

RPI-1 is a cell-permeable, indolinone-based ATP-competitive tyrosine kinase inhibitor that is known to target Ret, EGFR, and Met. Increased tumorigenicity, motility, and invasiveness have been described as biological consequences of HGF/Met deregulation in tumor cells, thus RPI-1 treatment of H460 cells resulted in a strong reduction of both colony number and size. The compound is also active at mouse NSCLC H460 xenograft tumor and metastasis model. Mechanistically RPI-1 inhibits Met phosphorylation at Tyr1234/Tyr1235, known to activate the intrinsic kinase activity. Selectively reverts the morphologic phenotype of ret oncogene- (PTC1 & MEN2A), but not H-Ras-, and transformed NIH3T3 in a reversible manner. RPI-1 effectively inhibits the autophosphorylation of PTC1, MEN2A, and Met against Met in N592 in cancer cells, and concomitant receptor down-regulation has also been reported to occur in NIH3T3MEN2A and in small cell lung carcinoma cell line N592. For the detailed information of RPI-1, the solubility of RPI-1 in water, the solubility of RPI-1 in DMSO, the solubility of RPI-1 in PBS buffer, the animal experiment (test) of  RPI-1, the cell expriment (test) of RPI-1, the in vivo, in vitro and clinical trial test of RPI-1, the EC50, IC50,and affinity,of RPI-1, Please contact DC Chemicals.