Chidamide supplier|DC Chemicals

Chidamide supplier|DC Chemicals
DC Chemicals provides Chidamide, other names: , cas: 743420-02-2. In stock.

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Chidamide is a class I HDAC inhibitor with IC50s of 95/160/67/733 nM for HDAC1/2/3/8; also inhibits HDAC10/11(IC50=78/432 nM); no inhibition on HDAC4/5/7/9/6(IC50>30 uM).

Chidamide, other names: , cas: 743420-02-2, Molecule formular: C22H19FN4O2, Molecule Weight: 390.41, Chemical name: N-​(2-​amino-​5-​fluorophenyl)-​4-​[[[1-​oxo-​3-​(3-​pyridinyl)-​2-​propen-​1-​yl]amino]methyl]-​benzamide

Chidamide(CS055; HBI-8000) is a class I HDAC inhibitor with IC50s of 95/160/67/733 nM for HDAC1/2/3/8; also inhibits HDAC10/11(IC50=78/432 nM); no inhibition on HDAC4/5/7/9/6(IC50>30 uM).Chidamide was able to increase the acetylation levels of histone H3 and to inhibit the PI3K/Akt and MAPK/Ras signaling pathways, which resulted in arresting colon cancer cells at the G1 phase of the cell cycle and promoting apoptosis [1]. chidamide inhibited class I HDACs 1–3, as well as class IIb HDAC10, at low nanomolar concentrations. Chidamide significantly induced histone H3 acetylation in both HeLa human cervical adenocarcinoma cells and human PBMC and the extent of induction was similar to that seen with MS-275 and SAHA [2]. Cell growth inhibition studies performed with 18 human-derived tumor cell lines demonstrated that chidamide and MS-275 similarly inhibited the in vitro growth of most, but not all, tumor cells in the low micromolar concentration range [2]. At low concentrations (<1 μM), CS055 induced G1 arrest. At moderate concentrations (0.5 μM-2 μM), CS055 induced differentiation, as determined by the increased expression of the myeloid differentiation marker CD11b. At relatively high concentrations (2 μM-4 μM), CS055 potently induced caspase-dependent apoptosis [3]. Chidamide treatment significantly decreased the expression of type I HDACs, uncleaved Caspase-3 and p21 and increased the ratio of Bax/Bcl-2 expression  For the detailed information of Chidamide, the solubility of Chidamide in water, the solubility of Chidamide in DMSO, the solubility of Chidamide in PBS buffer, the animal experiment (test) of  Chidamide, the cell expriment (test) of Chidamide, the in vivo, in vitro and clinical trial test of Chidamide, the EC50, IC50,and affinity,of Chidamide, Please contact DC Chemicals.