2015年4月1日星期三

CCG1423 supplier|CCG-1423|DC Chemicals

CCG1423 supplier|CCG-1423|DC Chemicals
DC Chemicals provides CCG1423, other names: CCG 1423,CCG-1423, cas: 285986-88-1. In stock.

Contact: website: www.dcchemicals.com,
sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,
Tel: +86-21-58447131;Fax:+86-21-61643309;

CCG-1423 is a novel inhibitor of RhoA/C-mediated gene transcription that is capable of inhibiting invasion of PC-3 prostate cancer cells in a Matrigel model of metastasis.

CCG1423, other names: CCG 1423,CCG-1423, cas: 285986-88-1, Molecule formular: C18H13ClF6N2O3, Molecule Weight: 454.75, Chemical name: N-[2-[4(4-chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)-benzamide

CCG-1423 is a novel inhibitor of RhoA/C-mediated gene transcription that is capable of inhibiting invasion of PC-3 prostate cancer cells in a Matrigel model of metastasis.CCG-1423 selectively inhibited spontaneous PC-3 prostate cancer cell invasion through a Matrigel matrix, but not the Gαi-dependent LPA-stimulated SKOV-3 ovarian cancer cell invasion, in vitro. At 100 μM, nearly complete inhibition of invasion was achieved with a lesser degree of toxicity than that induced by CCG-1423 at 10 μM [1]. SRF binds to this site in vivo and the SRF inhibitor CCG-1423 completely blocks STARS proximal reporter activity in H9c2 cells [3]. pharmacological MKL-inhibition with CCG-1423 significantly inhibited CCN1 promoter activity as well as mRNA and protein expression For the detailed information of CCG1423, the solubility of CCG1423 in water, the solubility of CCG1423 in DMSO, the solubility of CCG1423 in PBS buffer, the animal experiment (test) of  CCG1423, the cell expriment (test) of CCG1423, the in vivo, in vitro and clinical trial test of CCG1423, the EC50, IC50,and affinity,of CCG1423, Please contact DC Chemicals.

没有评论:

发表评论