SNS-062|SNS062|BTK inhibitor

SNS-062|SNS062|BTK inhibitor

DC Chemicals, Website: www.dcchemicals.com

Product Name: SNS-062|Cas Number: 1270014-40-8| Catalog Number: DC10488|Other Nmaes: SNS-062,SNK062,SNS 062

SNS-062 is a non-covalently binding inhibitor of Bruton's tyrosine kinase (BTK).

SNS-062 is a non-covalently binding inhibitor of Bruton's tyrosine kinase (BTK). This target mediates signaling through the B-cell receptor, or BCR, which is critical for adhesion, migration, proliferation and survival of normal and malignant B-lineage lymphoid cells. BTK has been well validated as a target for treatment of B-cell malignancies, with a BTK inhibitor approved for relapsed/refractory mantle cell lymphoma, relapsed/refractory chronic lymphocytic leukemia, or CLL, CLL with 17p depletion and Waldenström's macroglobulinemia. Because SNS-062 has demonstrated a distinct binding site and favorable pharmacokinetic profile in preclinical studies, SNS-062 may provide differentiated opportunities for treatment of B-cell malignancies and other blood cancers.