GSK-872|GSK872|RIPK3 inhibitor

GSK-872|GSK872|RIPK3 inhibitor

DC Chemicals, Website: www.dcchemicals.com

Product Name: GSK-872|Cas Number: 1346546-69-7| Catalog Number: DC10471|Other Nmaes: GSK-872,GSK 872,GSK872

GSK-872 is a potent and selective RIPK3 (receptor-interacting protein kinase-3) inhibitor.

GSK-872 is a cell-permeable quinolinyl-benzothiazolamine compound that is reported to act as a RIP3-selective kinase inhibitor with >1,000-fold selectivity over a vast majority of more than 300 other kinases, including RIP1. RIP1 inhibitor Nec-1 can be employed in conjunction with GSK'872 (3 µM) in delineating RIP1- vs. RIP3-dependency in Toll-like receptors- (TLRs) mediated necrosis and TNFR1-initiated necroptosis in the presence or absence of caspase inhibitor Z-VAD-FMK.