DDP-38003 dihydrochloride|cas 1831167-98-6

DDP-38003 dihydrochloride|cas 1831167-98-6

DC Chemicals, Website: www.dcchemicals.com

Product Name: DDP-38003 dihydrochloride|Cas Number: 1831167-98-6| Catalog Number: DC10413|Other Nmaes: DDP 38003 dihydrochloride; DDP38003 dihydrochloride

DDP-38003 dihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM.

DDP-38003 inhibits KDM1A with an IC50 of 84 nM. DDP-38003 is more active in reducing the colony forming ability and in inducing thedifferentiation of THP-1 cells compared to the 1R, 2S analogue[1].DDP-38003 exhibits in vivo efficacy after oral administration, determining a 62% increased survival in mouse leukemia models with evidence of KDM1A inhibition. The half life of DDP-38003 is 8 h. A significant dose dependent increase of mice survival is obtained by DDP-38003 treatment. The survival rate increases 35% and 62% at the dose of 11.25 and 22.50 mg/kg, respectively. DDP-38003 is a potential oral anticancer agent[1].