CF-102(CF102,2-Cl-IB-MECA)|A3 adenosine receptor agonist

CF-102(CF102,2-Cl-IB-MECA)|A3 adenosine receptor agonist

DC Chemicals, Website: www.dcchemicals.com

Product Name: CF-102(2-Cl-IB-MECA)|Cas Number: 163042-96-4| Catalog Number: DC10440|Other Nmaes: CF102; CF-102; CF 102; Cl-IB-MECA; 2-Cl-IB-MECA

CF-102(2-Cl-IB-MECA) is a selective A3 adenosine receptor agonist (Ki = 0.33 nM). Displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively.
target: A3 adenosine receptor agonist;

2-Cl-IB-MECA is a selective A3 adenosine receptor agonist (Ki = 0.33 nM). Displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively.
In vitro: In human ADF cells of astroglial lineage, 100 nM Cl-IB-MECA caused a marked reorganization of the cytoskeleton, with appearance of stress fibres and numerous cell protrusions. High concentrations of Cl-IB-MECA directly cause influx of Ca2+.
In vivo: Intravenous administration of 200 μg/kg 2-Cl-IB-MECA resulted in a short-lasting hypotension, which was accompanied by a 50–100-fold increase in plasma histamine concentrations. Administration of a second dose of 2-Cl-IB-MECA did not elicit any hemodynamic effects.