BKT140 |cas 664334-36-5

BKT140 |cas 664334-36-5

DC Chemicals, Website: www.dcchemicals.com

Product Name: BKT140|Cas Number: 664334-36-5| Catalog Number: DC10423|Other Nmaes: BL-8040; TF14016; 4F-Benzoyl-TN14003

BKT140 is a novel CXCR4 antagonist with an IC50 vakue of ～1 nM.

BKT140 displays selective toxicity toward AmL and MM cells. Treatment with BKT140 can overcome IL-6 dependent proliferation and survival of ARH77 MM cells. BKT140 specifically triggers CXCR4-dependent cell death in leukemia and MM cells. BKT140 stimulates apoptotic cell death in leukemia and MM cells[2].Subcutaneous injections of BKT140 significantly reduces, in a dose-dependent manner, the growth of human acute myeloid leukemia and multiple myeloma xenografts. Tumors from animals treated with BKT140 are smaller in size and weights, had larger necrotic areas and high apoptotic scores[2].