BIA 10-2474|cas 1233855-46-3

BIA 10-2474|cas 1233855-46-3

DC Chemicals, Website: www.dcchemicals.com

Product Name: BIA 10-2474|Cas Number: 1233855-46-3| Catalog Number: DC10404|Other Nmaes: BIA10-2474; BIA-10-2474

BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH) with IC50 values of 50 to 70mg/kg in various rat brain regions.

ExVivo: BIA 10-2474 proves to be a potent FAAH inhibitor with IC50s of 50-70mg/kg (i.p.) in various brain regions. IC50 values for brain regions are 52 (cerebellum), 67 (rest of brain), 68 (cortex), and 71 mg/kg (hypothalamus)[1].In January 2016, severe adverse events (SAE) occurs in the Phase I clinical trial using the drug BIA 10-2474 including one death. The possibilities for failure of trials such as off-target effect, dose calculation, unexpected immune response, species variation, and cumulative dose toxicity would be sought[2].