FRAX-486 supplier|FRAX486|DC Chemicals

FRAX-486 supplier|FRAX486|DC Chemicals
DC Chemicals provides FRAX-486, other names: FRAX 486,FRAX486, cas: 1232030-35-1. In stock.

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FRAX486 is a selective inhibitor of group I PAKs with IC50s of 8.25/39.5, /55.3 nM for PAK1/PAK2/PAK3 respectivelt; less potent for PAK4(IC50=779 nM).

FRAX-486, other names: FRAX 486,FRAX486, cas: 1232030-35-1, Molecule formular: C25H23Cl2FN6O, Molecule Weight: 513.39, Chemical name: 6-(2,4-Dichlorophenyl)-8-ethyl-2-[[3-fluoro-4-(1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one

FRAX486 is a selective inhibitor of group I PAKs with IC50s of 8.25/39.5, /55.3 nM for PAK1/PAK2/PAK3 respectivelt; less potent for PAK4(IC50=779 nM).FRAX486 is an inhibitor of PAK, with excellent selectivity for group I over group II PAKs [1].  Different from W-7 and KN-62, FRAX355 and FRAX486 did not completely block the NMDA-R activation-mediated spine enlargement in the presence of control RNAi, suggesting that these FRAX compounds act less aversely to the synaptic plasticity  For the detailed information of FRAX-486, the solubility of FRAX-486 in water, the solubility of FRAX-486 in DMSO, the solubility of FRAX-486 in PBS buffer, the animal experiment (test) of  FRAX-486, the cell expriment (test) of FRAX-486, the in vivo, in vitro and clinical trial test of FRAX-486, the EC50, IC50,and affinity,of FRAX-486, Please contact DC Chemicals.