Bilastine supplier||DC Chemicals

Bilastine supplier||DC Chemicals
DC Chemicals provides Bilastine, other names: , cas: 202189-78-4. In stock.

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Bilastine is a selective histamine H1 receptor antagonist used for treatment of allergic rhinoconjunctivitis and urticaria.

Bilastine, other names: , cas: 202189-78-4, Molecule formular: C28H37N3O3, Molecule Weight: 463.61, Chemical name: N-((S)-1-amino-3-(3-fluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxamide hydrochloride

Bilastine is a selective histamine H1 receptor antagonist used for treatment of allergic rhinoconjunctivitis and urticaria.Bilastine binds to histamine H1-receptors as indicated by its displacement of [3H]-pyrilamine from H1-receptors expressed in guinea-pig cerebellum and human embryonic kidney (HEK) cell lines. The studies conducted on guinea-pig smooth muscle demonstrated the capability of bilastine to antagonise H1-receptors. Bilastine is selective for histamine H1-receptors as shown in receptor-binding screening conducted to determine the binding capacity of bilastine to 30 different receptors [1]. Bilastine distribution has an apparent volume of distribution of 1.29 L/kg, and has an elimination half-life of 14.5 h and plasma protein binding of 84-90%  For the detailed information of Bilastine, the solubility of Bilastine in water, the solubility of Bilastine in DMSO, the solubility of Bilastine in PBS buffer, the animal experiment (test) of  Bilastine, the cell expriment (test) of Bilastine, the in vivo, in vitro and clinical trial test of Bilastine, the EC50, IC50,and affinity,of Bilastine, Please contact DC Chemicals.