BAY87-2243 supplier||DC Chemicals
DC Chemicals provides BAY87-2243, other names: , cas: 1227158-85-1. In stock.
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BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced HIF-1 activation.
BAY87-2243, other names: , cas: 1227158-85-1, Molecule formular: C26H26F3N7O2, Molecule Weight: 525.53, Chemical name: 1-cyclopropyl-4-[4-[[5-methyl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]-1H-pyrazol-1-yl]methyl]-2-pyridinyl]-piperazine
BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced HIF-1 activation.BAY 87-2243 inhibited luciferase activity with a calculated IC50 value of ~0.7 nmol/L. Hypoxic induction of the HIF target gene CA9 on protein level in HCT116luc cells was inhibited by BAY 87-2243 with an IC50 value of ~2.0 nmol/L. BAY 87-2243 has no effect on PHD-2 activity. BAY 87-2243 activity depends on intact VHL protein and PHD activity. Lead structure BAY 87-2243 was found to inhibit HIF-1α and HIF-2α protein accumulation under hypoxic conditions in non-small cell lung cancer (NSCLC) cell line H460 but had no effect on HIF-1α protein levels induced by the hypoxia mimetics desferrioxamine or cobalt chloride [1]. The combination treatment of BAY 87-2243 with regorafenib resulted in slight regression of tumor growth that was maintained for up to 18 days in A549. Combination of BAY 87-2243 and regorafenib resulted in an additive improvement of the tumor growth inhibition as compared to either agents alone in PC-3 For the detailed information of BAY87-2243, the solubility of BAY87-2243 in water, the solubility of BAY87-2243 in DMSO, the solubility of BAY87-2243 in PBS buffer, the animal experiment (test) of BAY87-2243, the cell expriment (test) of BAY87-2243, the in vivo, in vitro and clinical trial test of BAY87-2243, the EC50, IC50,and affinity,of BAY87-2243, Please contact DC Chemicals.
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