DC Chemicals supplies: WHI-P154,cas: 211555-04-3,Catalog: DC7581,In stock.
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Product name: WHI-P154, Synonyms: , cas: 211555-04-3, MW: 376.2, Molecule Formula: C16H14BrN3O3
WHI-P154, cas 211555-04-3, Purity>98%. Best price and quality from DC Chemicals.
WHI-P154 is first described as a JAK3 inhibitor that displays no activity at JAK1 or JAK2. WHI-P154 inhibits STAT1 activation, iNOS expression and NO production in macrophages in vitro. But it is proved that WHI-P154 also inhibits other common kinases including EGFR, Src, Abl, VEGFR, MAPK and PI3-K and induces apoptosis in human glioblastoma cell lines. [1] WHI-P154 inhibits glioblastoma cell adhesion and migration in the context of ECM.[2] WHI-P154 exhibits significant cytotoxicity against U373 and U87 human glioblastoma cell lines, causing apoptotic cell death at micromolar concentrations. The in vitro antiglioblastoma activity of WHI-P154 is amplified > 200-fold and rendered selective by conjugation to recombinant human epidermal growth factor (EGF). In vitro treatment with EGF-P154 results killing of glioblastoma cells at nanomolar concentrations with an IC50 of 813 nM, whereas no cytotoxicity against EGF-R-negative leukemia cellsis observed, even at concentrations as high as 100 mM.[3] The in vivo administration of EGF-P154 results in delayed tumor progression and improved tumor-free survival in a severe combined immunodeficient mouse glioblastoma xenograft model. Whereas none of the control mice remain alive tumor-free beyond 33 days (median tumor-free survival, 19 days) and all control mice have tumors that rapidly progress to reach an average size of > 500 mm3 by 58 days, 40% of mice treated For 10 consecutive days with 1 mg/kg/day EGF-P154 remain alive and free of detectable tumors For more than 58 days with a median tumor-free survival of 40 days. The tumors developing in the remaining 60% of the mice never reache a size > 50 mm3.[3]For the detailed information of WHI-P154, the solubility of WHI-P154 in water, the solubility of WHI-P154 in DMSO, the solubility of WHI-P154 in PBS buffer, the animal experiment (test) of WHI-P154, the cell expriment (test) of WHI-P154, the in vivo, in vitro and clinical trial test of WHI-P154, the EC50, IC50,and Affinity of WHI-P154, Please contact DC Chemicals.
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