DC Chemicals supplies: VcMMAE,cas: ,Catalog: DC7556,In stock.
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Product name: VcMMAE, Synonyms: VC-MMAE,Vc MMAE, cas: , MW: 1316.63, Molecule Formula: C68H105N11O15
VcMMAE, Purity:99.11%.Highest Purity in the market at the moment. Best price and quality from DC Chemicals. TC-DAPK 6 is an oxazalone compound that acts as a potent, ATP-competitive, and highly selective death-associated protein kinase (DAPK) inhibitor (IC50 = 69 and 225 nM against DAPK1 and DAPK3, respectively, with 10 uM ATP).
VcMMAE is an antibody-drug conjugate (ADC) with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).
IC50 value:
Target: Antibody-drug conjugate; Tubulin
Monomethyl auristatin E is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin.
Antibody-drug conjugates (ADCs) are designed to combine the exquisite specificity of antibodies to target tumor antigens with the cytotoxic potency of chemotherapeutic drugs. In vivo studies demonstrated that the peptide-linked conjugates induced regressions and cures of established tumor xenografts with therapeutic indices as high as 60-fold. These conjugates illustrate the importance of linker technology, drug potency and conjugation methodology in developing safe and efficacious mAb-drug conjugates For cancer therapy.For the detailed information of VcMMAE, the solubility of VcMMAE in water, the solubility of VcMMAE in DMSO, the solubility of VcMMAE in PBS buffer, the animal experiment (test) of VcMMAE, the cell expriment (test) of VcMMAE, the in vivo, in vitro and clinical trial test of VcMMAE, the EC50, IC50,and Affinity of VcMMAE, Please contact DC Chemicals.
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