Triapine supplier||DC Chemicals

Triapine supplier||DC Chemicals
DC Chemicals provides Triapine, other names: , cas: 143621-35-6. In stock.

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Triapine(NSC663249; OCX191; PAN-811) is a ribonucleotide reductase inhibitor, has been extensively evaluated in clinical trials in the last decade; CDK inhibtor.

Triapine, other names: , cas: 143621-35-6, Molecule formular: C7H9N5S, Molecule Weight: 195.24, Chemical name: 3-​Aminopyridine-​2-​carboxaldehyde thiosemicarbazone 3-AP PAN-811

Triapine(NSC663249; OCX191; PAN-811) is a ribonucleotide reductase inhibitor, has been extensively evaluated in clinical trials in the last decade; CDK inhibtor.3-AP and 3-AP-Me activated the cellular stress kinases c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases, and inhibition of JNK activity antagonized the cytotoxic effect of both compounds. 3-AP and 3-AP-Me induce apoptosis via ER stress [1].  Triapine abolishes olaparib-induced BRCA1 and Rad51 foci, and disrupts the BRCA1 interaction with the Mre11-Rad50-Nbs1 (MRN) complex in BRCA1 wild-type EOC cells. triapine inhibits cyclin-dependent kinase (CDK) activity and blocks olaparib-induced CtIP phosphorylation through Chk1 activation. triapine abrogates etoposide-induced CtIP phosphorylation and DSB resection as evidenced by marked attenuation of RPA32 phosphorylation  For the detailed information of Triapine, the solubility of Triapine in water, the solubility of Triapine in DMSO, the solubility of Triapine in PBS buffer, the animal experiment (test) of  Triapine, the cell expriment (test) of Triapine, the in vivo, in vitro and clinical trial test of Triapine, the EC50, IC50,and affinity,of Triapine, Please contact DC Chemicals.