TAK-599 (ceftaroline fosamil) |PPI-0903|Provide by DC CHEM
DC Chemicals provides TAK-599 (ceftaroline fosamil), other names: TAK-599, ceftaroline fosamil,TAK599, TAK 599,PPI-0903,PPI0903,PPI 0903, cas: 400827-46-5. In stock.
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TAK-599 is a highly promising parenteral cephalosporin targeted for MRSA infection.
TAK-599 (ceftaroline fosamil), other names: TAK-599, ceftaroline fosamil,TAK599, TAK 599,PPI-0903,PPI0903,PPI 0903, cas: 400827-46-5, Molecule formular: C24H25N8O10PS4, Molecule Weight: 744.73, Chemical name:
TAK-599 (known as ceftaroline fosamil) is a novel N-phosphono type prodrug of a cephalosporin compound.Crystalline 1 (TAK-599) is a novel N-phosphono prodrug of anti-methicillin-resistant Staphylococcus aureus (MRSA) cephalosporin 2a (T-91825) that has high affinity for penicillin-binding protein (PBP) 2' (IC(50); 0.90 microg/mL) and shows potent in vitro anti-MRSA activity (MIC against MRSA N133; 1.56 microg/mL), comparable to that of vancomycin (1.56 microg/mL). Although 2a had insufficient water solubility (2.3 mg/mL) for parenteral administration, 1 showed excellent water solubility (>100 mg/mL, pH 7) as well as good chemical stability in the solid state and solution. In pharmacokinetic studies, when 1 was administered intravenously to rats and monkeys, it was rapidly converted into 2a in the blood. These results show that 1 (TAK-599) is a highly promising parenteral cephalosporin targeted for MRSA infection. For the detailed information of TAK-599, the solubility of TAK-599 in water, the solubility of TAK-599 in DMSO, the solubility of TAK-599 in PBS buffer, the animal experiment (test) of TAK-599, the cell expriment (test) of TAK-599, the in vivo, in vitro and clinical trial test of TAK-599, the EC50, IC50,and affinity,of TAK-599, Please contact DC Chemicals.
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