DC Chemicals supplies: SIRT2 Inhibitor II, AK-7,cas: 420831-40-9,Catalog: DC7540,In stock.
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Product name: SIRT2 Inhibitor II, AK-7, Synonyms: AK-7,AK7,AK 7, cas: 420831-40-9, MW: 437.4 , Molecule Formula: C19H21BrN2O3S
SIRT2 Inhibitor II, AK-7, cas 420831-40-9, Purity>98%. Best price and quality from DC Chemicals. SIRT2 Inhibitor II, AK-1 inhibits SIRT2 selectively over SIRT1 and SIRT3.
The sirtuin SIRT2 is a deacetylase which targets α-tubulin, histone 4, Forkhead transcription factors, and several other substrates.1 It has roles in metabolic diseases, cancer, age-related disorders, and neurodegenerative diseases, potentially including Alzheimer’s, Huntington’s, and Parkinson’s diseases.AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM).In culture, it dimishes neuronal cell death induced by mutant huntingtin fragment.In addition, AK-7 down-regulates cholesterol biosynthetic gene expression and reduces total cholesterol levels in neurons in vivo.For the detailed information of SIRT2 Inhibitor II, AK-7, the solubility of SIRT2 Inhibitor II, AK-7 in water, the solubility of SIRT2 Inhibitor II, AK-7 in DMSO, the solubility of SIRT2 Inhibitor II, AK-7 in PBS buffer, the animal experiment (test) of SIRT2 Inhibitor II, AK-7, the cell expriment (test) of SIRT2 Inhibitor II, AK-7, the in vivo, in vitro and clinical trial test of SIRT2 Inhibitor II, AK-7, the EC50, IC50,and Affinity of SIRT2 Inhibitor II, AK-7, Please contact DC Chemicals.
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