SH-4-54 supplier||DC Chemicals

SH-4-54 supplier||DC Chemicals
DC Chemicals provides SH-4-54, other names: , cas: 1456632-40-8. In stock.

Contact: website: www.dcchemicals.com,
sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,
Tel: +86-21-58447131;Fax:+86-21-61643313；

SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively.

SH-4-54, other names: , cas: 1456632-40-8, Molecule formular: C29H27F5N2O5S, Molecule Weight: 610.59, Chemical name: 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-benzoic acid

SH-4-54 strongly binds to STAT3 protein (K D = 300 nM). SH-4-54 potently kills glioblastoma brain cancer stem cells (BTSCs) and effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets at low nM concentrations. SH-4-54 exhibites blood-brain barrier permeability, potently controlled glioma tumor growth, and inhibites pSTAT3 in vivo.

 For the detailed information of SH-4-54, the solubility of SH-4-54 in water, the solubility of SH-4-54 in DMSO, the solubility of SH-4-54 in PBS buffer, the animal experiment (test) of  SH-4-54, the cell expriment (test) of SH-4-54, the in vivo, in vitro and clinical trial test of SH-4-54, the EC50, IC50,and affinity,of SH-4-54, Please contact DC Chemicals.