DC Chemicals supplies: NVP-ADW742,cas: 475489-15-7,Catalog: DC7549,In stock.
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Product name: NVP-ADW742, Synonyms: ADW742, cas: 475489-15-7, MW: 453.58, Molecule Formula: C28H31N5O
NVP-ADW742, cas 475489-15-7, Purity>98%. Best price and quality from DC Chemicals. Nexturastat A is a potent and selective HDAC6 inhibitor with IC50 of 5 nM, >190-fold selectivity over other HDACs.
NVP-ADW742 exhibits a 6-fold greater selectivity For IGF-1R versus InsR with IC50 of 2.8 μM; minimal inhibitory activity against c-Kit, HER1, PDGFR, VEGFR2, or Bcr-Abl p210 with IC50 greater than 5 μM. NVP-ADW742 significantly inhibits the serum-stimulated cell proliferation in a variety of tumor cell lines in dose-dependent manner, with IC50 values of 0.1-0.5 μM For the multiple myeloma (MM) cell lines, and the antitumor effects on MM cells can not be overcome by the co-culture with BMSCs. NVP-ADW742 also abrogates the responsiveness of tumor cells to IL-6 in the presence of serum. In addition, NVP-ADW742 is active against MM cell lines with resistance to conventional (cytotoxic chemotherapy, dexamethasone) or investigational (thalidomide, CC-5013, TRAIL/Apo2L, PS-341) anticancer agents, as well as primary tumor cells from MM patients with multi-drug-resistant disease. NVP-ADW742 decreases the production of VEGF by tumor cells and bone marrow stromal cells, and suppresses the IGF-1-induced secretion of VEGF by various tumor types such as thyroid cancer cells or MM cells. IGF-1R inhibition by NVP-ADW742 (0.75 μM) sensitizes MM cells or prostate cancer cells to other anticancer agents such as doxorubicin, melphalan, dexamethasone, TRAIL/Apo2L, or PS-341. [1] Administration of NVP-ADW742 at 10 mg/kg twice daily significantly inhibits tumor growth, prolongs survival, and enhances the antitumor effect of cytotoxic chemotherapy melphalan in the mice model of diffuse MM. [1]For the detailed information of NVP-ADW742, the solubility of NVP-ADW742 in water, the solubility of NVP-ADW742 in DMSO, the solubility of NVP-ADW742 in PBS buffer, the animal experiment (test) of NVP-ADW742, the cell expriment (test) of NVP-ADW742, the in vivo, in vitro and clinical trial test of NVP-ADW742, the EC50, IC50,and Affinity of NVP-ADW742, Please contact DC Chemicals.
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