AZ-6102 (AZ6102),TNKS inhibitor From DC CHEM

AZ-6102 (AZ6102),TNKS inhibitor From DC CHEM
DC Chemicals provides AZ-6102, other names: AZ-6102,AZ6102,AZ 6102, cas: N/A. In stock.

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AZ6102 is a tankyrase 1 and 2 inhibitor (TNKS1/2) inhibitor.

AZ-6102, other names: AZ-6102,AZ6102,AZ 6102, cas: N/A, Molecule formular: C25H28N6O, Molecule Weight: 428.2, Chemical name:

AZ6102 inhibits TNKS1 and TNKS2 in enzymatic assays and TCF4 reporter assays (<5nM).AZ6102 inhibits proliferation of Colo320DM (GI50 ~40nM), but has no anti-proliferative activity in the β-catenin mutant cell line HCT-116, or the BRCA mutant cell line MDA-MB-436. In Colo320DM, AZ6102 stabilizes axin2 protein and modulates Wnt target genes in a dose and time dependent manner both in vitro and in vivo.For the detailed information of AZ-6102, the solubility of AZ-6102 in water, the solubility of AZ-6102 in DMSO, the solubility of AZ-6102 in PBS buffer, the animal experiment (test) of  AZ-6102, the cell expriment (test) of AZ-6102, the in vivo, in vitro and clinical trial test of AZ-6102, the EC50, IC50,and affinity,of AZ-6102, Please contact DC Chemicals.