Vipadenant(BIIB-014) is an adenosine A2a antagonist with Ki of 1.3 nM; less potent for A1(Ki=69 nM).
Product Name: Vipadenant|Cat No.:DC8814|CAS: 442908-10-3|Other names: BIIB-014,BIIB 014,BIIB014|MW: 321.34|C16H15N7O
Vipadenant showed excellent binding affinity for A2A and had modest selectivity against A1 and A2B (Ki = 63 nM), while it showed good selectivity against A3 (Ki = 1005 nM). Vipadenant was able to increase contralateral rotations in 6-OHDA lesioned rats when dosed orally in combination with apomorphine at 3 and 10 mg/kg.
For research only, not for human use!
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