L-778123 hydrochloride is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination.
Product Name: L-778123 HCl|Cat No.:DC8803|CAS: 253863-00-2|Other names: L-778123,L 778123,L778123|MW: 405.88|C22H20ClN5O
L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. The combination of L-778,123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Radiosensitization of a patient-derived pancreatic cancer cell line was observed .
For research only, not for human use!
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