TPI-1|TAP1|SHP-1 inhibitor

TPI-1|TAP1|SHP-1 inhibitor

DC Chemicals, Website: www.dcchemicals.com

Product Name: TPI-1|Cas Number: 79756-69-7| Catalog Number: DC10088|Other Nmaes: TPI1,TPI 1

TPI-1 is a potent and selective SHP-1 inhibitor effective at low nanomolar levels.

TPI-1 is a potent and
selective SHP-1 inhibitor effective at low nanomolar levels. TPI-1 inhibited recombinant SHP-1 with IC50 at ∼10 ng/ml
(and increased SHP-1 phospho-substrates pLck-pY394,
pZap70, and pSlp76 in Jurkat T cells starting at 10 ng/ml.
Its selectivity was indicated by its reduced effectiveness foTPI-1 increases IFN-g+ cells in mouse splenocytes and human
peripheral blood in vitro.TPI-1 increases mouse spleen pLck-pY394 and IFN-g+ cells
in vivo.TPI-1 inhibits the growth of B16 melanoma tumors in mice as
a tolerated single agent