EC330 |cas 2016795-77-8

EC330 |cas 2016795-77-8

DC Chemicals, Website: www.dcchemicals.com

Product Name: EC330|Cas Number: 2016795-77-8| Catalog Number: DC10277|Other Nmaes: EC-330; EC 330

EC330 is a leukemia inhibitory factor (LIF) inhibitor.

EC330 shows marked specificity in MCF-7 cells overexpressing LIF verses MCF-7 cells. EC330 further shows cytoskeletal disruption and targeting cancer-associated fibroblasts (CAFs) through inhibition of alpha-SMA but not beta-tubulin[1].EC330 treatment (0.1, 0.5 and 2.5 mg/kg) dose dependently reduces tumor burden in ovarian (IGROV-1) and triple negative breast cancer (MDA-MB-231) cell xenografted mouse models as well as MDA-MB-231 PDX models. EC330 exhibits no reactivity towards thiol-cysteine residues, no off target binding to major receptors, kinases or ion channels. EC330 is orally bioavailable and found to be safe and tolerable in toxicity studies[1].